Vol 63 No 3 (2018): Journal of the Chilean Chemical Society
Original Research Papers


Noor Ul Amin Mohsin
Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Government College University Faisalabad
Muhammad Irfan
Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, Government College University Faisalabad
Published September 12, 2018
  • Resveratrol (RSV),
  • Wittig reaction,
  • aldol condensation,
  • natural molecules,
  • antitumor activity,
  • anti-Alzheimer activity
  • ...More


 Resveratrol (RSV) is a polyphenol produced by different plant species having a variety of biological activities. Synthesis of hybrid molecules of RSV with different natural and synthetic compounds has been studied. These hybrid molecules have been prepared by using fused or merged techniques or by using some linker groups. Wittig method was mostly applied by using the appropriate ylides to prepare the RSV core. The hybrid molecules prepared by these techniques exhibited anticancer, anti-inflammatory, antioxidant, anti-alzheimer, metal chelating and enzyme inhibitory activities. These hybrid RSV molecules can serve as a lead compounds for the future design of new drug molecules.



  1. H. Van Poppel and B. Tombal, Cancer Manag. Res. 3, 91, (2011).
  2. Altern. Med. Rev. 15, 152, (2010).
  3. N. Y. Anisimova, M. V. Kiselevsky, A. V. Sosnov, S. V. Sadovnikov, I. N. Stankov and A. A. Gakh, Chem. Cent. J. 5, 88, (2011).
  4. A. Koeberle and O. Werz, Drug Discovery Today 19, 1871, (2014).
  5. K. A. Ahmad, N. H. Harris, A. D. Johnson, H. C. Lindvall, G. Wang and K. Ahmed, Mol. Cancer Ther. 6, 1006, (2007).
  6. J. A. Baur and D. A. Sinclair, Nat. Rev. Drug Discov. 5, 493, (2006).
  7. S. Das and D. K. Das, Recent Pat. Cardiovasc. Drug Discov. 2, 133, (2007).
  8. M. E. Juan, I. Alfaras and J. M. Planas, Pharmacol. Res. 65, 584, (2012).
  9. M. Sengottuvelan, R. Senthilkumar and N. Nalini, Biochim Biophys Acta 1760, 1175, (2006).
  10. H. Gwak, G. Haegeman, B. K. Tsang and Y. S. Song, Mol. Carcinog. 54, 1529, (2015).
  11. E. Scott, W. P. Steward, A. J. Gescher and K. Brown, Mol. Nutr. Food Res. 56, 7, (2012).
  12. J. Tome-Carneiro, M. Larrosa, A. Gonzalez-Sarrias, F. A. Tomas- Barberan, M. T. Garcia-Conesa and J. C. Espin, Curr. Pharm. Des. 19, 6064, (2013).
  13. T. Walle, Ann. N.Y. Acad. Sci. 1215, 9, (2011).
  14. F. Belluti, G. Fontana, L. Dal Bo, N. Carenini, C. Giommarelli and F. Zunino, Bioorg. Med. Chem. 18, 3543, (2010).
  15. B. Meunier, Acc. Chem. Res. 41, 69, (2007).
  16. J. R. Morphy, Designing Multi-Target Drugs, 141, (2012).
  17. M. J. Matos, F. Mura, S. Vazquez-Rodriguez, F. Borges, L. Santana, E. Uriarte and C. Olea-Azar, Molecules 20, 3290, (2015).
  18. W. Shen, J. Mao, J. Sun, M. Sun and C. Zhang, Med. Chem. Res. 22, 1630, (2013).
  19. O. Gia, S. M. Magno, H. Gonzalez-Diaz, E. Quezada, L. Santana, E. Uriarte and L. Dalla Via, Biorg. Med. Chem. 13, 809, (2005).
  20. S. Vilar, E. Quezada, L. Santana, E. Uriarte, M. Yánez, N. Fraiz, C. Alcaide, E. Cano and F. Orallo, Bioorg. Med. Chem. Lett. 16, 257, (2006).
  21. X.-F. Huang, B.-F. Ruan, X.-T. Wang, C. Xu, H.-M. Ge, H.-L. Zhu and R.-X. Tan, Eur. J. Med. Chem. 42, 263, (2007).
  22. J. Pan, T. Xu, F. Xu, Y. Zhang, Z. Liu, W. Chen, W. Fu, Y. Dai, Y. Zhao and J. Feng, Eur. J. Med. Chem. 125, 478, (2017).
  23. D. Kumar, K. K. Raj, S. V. Malhotra and D. S. Rawat, MedChemComm 5, 528, (2014).
  24. W. Chen, X. Ge, F. Xu, Y. Zhang, Z. Liu, J. Pan, J. Song, Y. Dai, J. Zhou, J. Feng and G. Liang, Bioorg. Med. Chem. Lett. 25, 2998, (2015).
  25. L. Al-Riyami, M. A. Pineda, J. Rzepecka, J. K. Huggan, A. I. Khalaf, C. J. Suckling, F. J. Scott, D. T. Rodgers, M. M. Harnett and W. Harnett, J. Med. Chem. 56, 9982, (2013).
  26. S. Li, W. Zhang, Y. Yang, T. Ma, J. Guo, S. Wang, W. Yu and L. Kong, Eur. J. Med. Chem. 124, 1006, (2016).
  27. F. S. Aldawsari, O. H. Elshenawy, M. A. El Gendy, R. Aguayo-Ortiz, S. Baksh, A. O. El-Kadi and C. A. Velázquez-Martínez, J. Enzyme Inhib. Med. Chem. 30, 884, (2015).
  28. F. S. Aldawsari, R. Aguayo-Ortiz, K. Kapilashrami, J. Yoo, M. Luo, J. L. Medina-Franco and C. A. Velázquez-Martínez, J. Enzyme Inhib. Med. Chem. 31, 695, (2016).
  29. F. S. Aldawsari, R. P. Aguiar, L. A. M. Wiirzler, R. Aguayo-Ortiz, N. Aljuhani, R. K. N. Cuman, J. L. Medina-Franco, A. G. Siraki and C. A. Velázquez-Martínez, Bioorg. Med. Chem. Lett. 26, 1411, (2016).
  30. X. Yang, X. Qiang, Y. Li, L. Luo, R. Xu, Y. Zheng, Z. Cao, Z. Tan and Y. Deng, Bioorg. Chem. 71, 305, (2017).
  31. J. Yang, G. Y. Liu, D. L. Lu, F. Dai, Y. P. Qian, X. L. Jin and B. Zhou, Chemistry-A European Journal 16, 12808, (2010).
  32. L. A. Dutra, J. F. O. Guanaes, N. Johmann, M. E. L. Pires, C. M. Chin, S. Marcondes and J. L. Dos Santos, Bioorg. Med. Chem. Lett. 27, 2450, (2017).
  33. M. Murty, R. Penthala, S. Polepalli and N. Jain, Med. Chem. Res. 25, 627, (2016).
  34. J. Jeřábek, E. Uliassi, L. Guidotti, J. Korábečný, O. Soukup, V. Sepsova, M. Hrabinova, K. Kuča, M. Bartolini and L. E. Pena-Altamira, Eur. J. Med. Chem. 127, 250, (2017).
  35. F. Mao, J. Yan, J. Li, X. Jia, H. Miao, Y. Sun, L. Huang and X. Li, Org. Biomol. Chem. 12, 5936, (2014).
  36. C. Lu, Y. Guo, J. Yan, Z. Luo, H.-B. Luo, M. Yan, L. Huang and X. Li, J. Med. Chem. 56, 5843, (2013).
  37. P. Xu, M. Zhang, R. Sheng and Y. Ma, Eur. J. Med. Chem. 127, 174, (2017).
  38. A. Kamal, M. Ashraf, S. T. Basha, S. A. Hussaini, S. Singh, M. Vishnuvardhan, B. Kiran and B. Sridhar, Org. Biomol. Chem. 14, 1382, (2016).
  39. S. Park, J. K. Seok, J. Y. Kwak, Y.-H. Choi, S. S. Hong, H.-J. Suh, W. Park and Y. C. Boo, Archives of dermatological research 308, 325, (2016).
  40. N. A. Markina, Y. Chen and R. C. Larock, Tetrahedron 69, 2701, (2013).
  41. D. D. Vo and M. Elofsson, Adv. Synth. Catal. 358, 4085, (2016).

Copyright @2019 | Designed by: Open Journal Systems Chile Logo Open Journal Systems Chile Support OJS, training, DOI, Indexing, Hosting OJS

Code under GNU license: OJS PKP