JOURNAL OF CHILEAN CHEMICAL SOCIETY

Vol 63 No 3 (2018): Journal of the Chilean Chemical Society
Original Research Papers

DETERMINATION OF HYDROXYZINE BY DIFFERENTIAL PULSE ANODIC VOLTAMMETRY USING CARBON PASTE ELECTRODE

Sayed I. M. Zayed
Chemistry Department, Faculty of Science, Taif University Faculty of Industrial Education, Beni-Suef University, Beni-Suef, Egypt
Amal A. H. Al-Talhi
Chemistry Department, Faculty of Science, Taif University
Asmaa E. Al Thagafi
Chemistry Department, Faculty of Science, Taif University
Published September 12, 2018
Keywords
  • Hydroxyzine dihydrochloride,
  • differential pulse anoding voltammetry,
  • carbon paste electrodes,
  • pharmaceutical dosage form,
  • human urine

Abstract

The electrochemical oxidation of hydroxyzine dihydrochloride at carbon paste electrode has been studied in 0.04 M Britton-Robinson buffer pH 6.2 using cyclic and differential pulse voltammetry. The oxidation process has been shown to irreversible and diffusion controlled with adsorption characterstics. Based on these studies, simple, rapid, and sensitive differential pulse anodic voltammetric method has been developed for the determination of the drug over the concentration range 0.45-5.36 μg/ml, with detection and quantification limits of 0.27 and 0.90 μg/ml hydroxyzine dihydrochloride, respectively. The proposed method was successfully used for quantification of hydroxyzine dihydrochloride in Atarax tablets and spiked human urine.

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